ISO/TS 4971 nanotechnology standard led by Taiwan has been published

The ISO/TS 4971 standard "Nanotechnologies - Performance Evaluation of Nanosuspension Containing Clay Nanoplates for Quorum Quenching" had published by ISO in June 2023. This standard is led by Asia Nano Forum (ANF), and project leaders are Dr. Tsing-Tang Song from ITRI Taiwan and Prof. Jiang-Jen Lin from National Taiwan University. ANF submitted this proposal to the ISO/TC 229 at the plenary meeting on 13 November 2019, and ISO/TC 229 approved it as a new project in April 2020.

This standard provides characteristics and measurement methods, including chemical composition, mineral composition, specific surface area, cation exchange capacity, hydrodynamic size, and zeta potential for the clay nanoplate. These essential characteristics of clay nanoplate can provide an understanding of the potential quorum quenching ability and antibacterial performance. This standard is used as the quality control of clay nanoplate, and more importantly, the quorum quenching ability and antimicrobial efficacy by using clay nanoplates can be measured and predicted. The clay nanoplate suspension in water is designed to inhibit the growth of pathogenic bacteria for crop protection from diseases. Moreover, as an additional benefit, harvesting yield increased.

This standard describes the measurement methods of the interaction of clay nanoplates with bacterial signaling molecules and bacterial surfaces, including the quorum quenching ability by surfactants, the determination of minimum inhibitory concentration, and determination of minimum bactericidal concentration. The relationship between clay nanoplate characteristics and antibacterial performance is described in Annex A. The correlation between quorum quenching ability and antibacterial performance is described in Annex B, and the safety of clay nanoplate is described in Annex C.